activated ppar targets surface and intracellular signals that inhibit the proliferation of lung carcinoma cells激活ppar目标表面和胞内信号,抑制肺癌细胞的增殖.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 254108, 8 pages doi:10.1155/2008/254108 Review Article Activated PPARγ Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells Shou Wei Han1 and Jesse Roman1, 2 1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, 615 Michael Street Suite 205, Atlanta, GA 30322, USA 2 Atlanta VA Medical Center, Department of Medicine, 1670 Clairmont Road, Decatur, GA 30033, USA Correspondence should be addressed to Shou Wei Han, shan2@ Received 28 April 2008; Accepted 24 June 2008 Recommended by Dipak Panigrahy Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, proliferation, and apoptosis, and the modulation of important biological and pathological processes related to inflammation and cancer biology, among others. Since then, PPARs have become an exciting target for the development of therapies directed at many disorders including cancer. PPARs are expressed in many tumors including lung cancer, and their function has been linked to the process of carcinogenesis. Consequently, intense research is being conducted in this area with the hope of discovering new PPAR-related therapeutic targets for the treatment of lung cancer. This review summarizes the research being conducted in this area, and focuses on the mechanisms by which a member of this family (PPARγ) is believed to affect lung tumor cell biology. Copyright © 2008 S. W