原创力文档activation of ppar by rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats激活的ppar罗格列酮并不在糖尿病大鼠雄性类固醇激素产生负面影响.pdfVIP
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activation of ppar by rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats激活的ppar罗格列酮并不在糖尿病大鼠雄性类固醇激素产生负面影响
Hindawi Publishing Corporation
PPAR Research
Volume 2009, Article ID 101857, 8 pages
doi:10.1155/2009/101857
Research Article
Activation of PPARγ by Rosiglitazone Does Not Negatively Impact
Male Sex Steroid Hormones in Diabetic Rats
Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz,
Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, and Edward Morrison
Department of Anatomy, Physiology and Pharmacology, Auburn University, AL 36849, USA
Correspondence should be addressed to Mahmoud Mansour, mansoma@
Received 22 December 2008; Revised 17 March 2009; Accepted 29 April 2009
Recommended by Carolyn Komar
Peroxisome proliferator-activated receptor gamma (PPARγ) activation decreased serum testosterone (T) in women with
hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. This
implies modulation of female sex steroid hormones by PPARγ. It is not clear if PPARγ modulates sex steroid hormones in diabetic
males. Because PPARγ activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long
term impact of PPARγ activation on steroid sex hormones in males is critical. Our objective was to determine the effect of PPARγ
activation on serum and intratesticular T, luteinizing hormone (LH), follicle stimulating hormone (FSH) and E2 concentrations in
male Zucker diabetic fatty (ZDF) rats treated with the PPARγ agonist rosiglitazone (a thiazolidinedione). Treatment for eight weeks
increased PPARγ mRNA and protein in the testis and elevated serum adiponectin, an adipokine marker for PPARγ activation.
PPARγ activation did not alter serum or intratesticular T concentrations. In contrast, serum T level but not intratesticular T was
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