activity-dependent callosal axon projections in neonatal mouse cerebral cortex新生儿的老鼠大脑皮层活动依赖性胼胝体轴突预测.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2012, Article ID 797295, 10 pages doi:10.1155/2012/797295 Review Article Activity-Dependent Callosal Axon Projections in Neonatal Mouse Cerebral Cortex Yoshiaki Tagawa1, 2 and Tomoo Hirano1 1 Department of Biophysics, Kyoto University Graduate School of Science, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan 2 CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan Correspondence should be addressed to Yoshiaki Tagawa, tagawa@neurosci.biophys.kyoto-u.ac.jp Received 31 July 2012; Accepted 21 October 2012 Academic Editor: Matteo Caleo Copyright © 2012 Y. Tagawa and T. Hirano. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Callosal axon projections are among the major long-range axonal projections in the mammalian brain. They are formed during the prenatal and early postnatal periods in the mouse, and their development relies on both activity-independent and -dependent mechanisms. In this paper, we review recent findings about the roles of neuronal activity in callosal axon projections. In addition to the well-documented role of sensory-driven neuronal activity, recent studies using in utero electroporation demonstrated an essential role of spontaneous neuronal activity generated in neonatal cortical circuits. Both presynaptic and postsynaptic neuronal activities are critically involved in the axon development. Studies have begun to reveal intracellular signaling pathway which works downstream of neuronal activity. We also review several distinct patterns of neuronal activity observed in the developing cerebral