a time course for susceptibility to staphylococcus aureus respiratory infection during influenza in a swine model一次课程对金黄色葡萄球菌呼吸道感染的易感性在猪流感模型.pdfVIP

Hindawi Publishing Corporation Influenza Research and Treatment Volume 2011, Article ID 846910, 10 pages doi:10.1155/2011/846910 Research Article A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model Elizabeth A. Smith,1 Sandeep R. P. Kumar,2 Jagadeeswaran Deventhiran,2 Thomas E. Cecere,2 Tanya LeRoith,2 Mike McGilliard,1 Subbiah Elankumaran,2 and Isis Kanevsky Mullarky1 1 Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA 2 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA Correspondence should be addressed to Isis Kanevsky Mullarky, mullarky@ Received 28 September 2011; Revised 16 December 2011; Accepted 16 December 2011 Academic Editor: Alicia Solorzano Copyright © 2011 Elizabeth A. Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bacterial superinfections following influenza A virus (IAV) are predominant causes of morbidity in humans. The recent emergence of methicillin-resistant Staphylococcus aureus (MRSA) and highly virulent IAV strains has reduced treatment options. Development of an appropriate animal model to study secondary S. aureus infections may provide important information regarding disease pathogenesis. Pigs are natural hosts to both IAV and S. aureus and have respiratory physiology and immune response comparable to humans. To establish a time course of susceptibility to S. aureus after IAV infection, nursery pigs infected intranasally with IAV were challenged with MR