activity of cathelicidin peptides against simkania negevensis抗菌肽活性肽对simkania negevensis.pdfVIP

Hindawi Publishing Corporation International Journal of Peptides Volume 2011, Article ID 708710, 3 pages doi:10.1155/2011/708710 Research Article Activity of Cathelicidin Peptides against Simkania negevensis Manuela Donati,1 Antonietta Di Francesco,2 Maria Di Paolo,1 Natascia Fiani,1 Monica Benincasa,3 Renato Gennaro,3 Paola Nardini,1 Claudio Foschi,1 and Roberto Cevenini1 1 Section of Microbiology DESOS, Policlinico S. Orsola, University of Bologna, 40138 Bologna, Italy 2 Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell’Emilia, Italy 3 Department of Life Sciences, University of Trieste, 34127, Trieste, Italy Correspondence should be addressed to Antonietta Di Francesco, antoniet.difrancesco@unibo.it Received 10 December 2010; Accepted 30 January 2011 Academic Editor: Peter Bergman Copyright © 2011 Manuela Donati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides—PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28—proved to be active at very low concentrations (1 to 0.1 µg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 µg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested. 1. Introduction mammalian leucocytes and show an antimicrobial activity against bacteria, fungi, pro