all-trans-retinoic acid ameliorated high fat diet-induced atherosclerosis in rabbits by inhibiting platelet activation and inflammationall-trans-retinoic酸改善高脂肪食源性兔动脉粥样硬化的抑制血小板激活和炎症.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 259693, 9 pages doi:10.1155/2012/259693 Research Article All-trans -Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation Birong Zhou,1, 2 Ying Pan,2 Zeping Hu,1 Xiaobian Wang,3 Jianxiong Han,3 Qing Zhou,3 Zhimin Zhai,2 and Yuan Wang3 1 Department of Cardiology, The First Affi liated Hospital of Anhui Medical University, Anhui 230022, China 2 Department of Hematology, The Second Affi liated Hospital of Anhui Medical University, Anhui 230601, China 3 Laboratory of Molecular Biology, Anhui Medical University, Anhui 230032, China Correspondence should be addressed to Zhimin Zhai, zhaizhimin01@126.com and Yuan Wang, wangyuan@ Received 2 November 2011; Revised 21 December 2011; Accepted 21 December 2011 Academic Editor: Saulius Butenas Copyright © 2012 Birong Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. All-trans-retinoic acid (atRA) is effective for many proliferative diseases. We investigated the protective effects of atRA against atherosclerosis. Methods. Rabbits were randomly allocated to receive basal diet or an HFD for 4 weeks. HFD group then received rosuvastatin (3 mg/day), atRA (5 mg/kg/day), or the same volume of vehicle, respectively, for next 8 weeks. Results. HFD group showed increases in plasma lipids and aortic plaque formation. P-selectin expression and fibrinogen binding on platelets or deposition on the intima of the aorta also increased significantly as did the levels of TNF-α, IL-6, and fibrinogen in plasma. After