alzheimer disease and oxidative stress阿尔茨海默病和氧化应激.pdfVIP

Journal of Biomedicine and Biotechnology • 2:3 (2002) 120–123 • PII. S1110724302203010 • REVIEW ARTICLE Alzheimer Disease and Oxidative Stress George Perry, Adam D. Cash, and Mark A. Smith∗ Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA Received 11 February 2002; accepted 18 March 2002 Research in Alzheimer disease has recently demonstrated compelling evidence on the importance of oxidative processes in its patho- genesis. Cellular changes show that oxidative stress is an event that precedes the appearance of the hallmark pathologies of the dis- ease, neurofibrillary tangles, and senile plaques. While it is still unclear what the initial source of the oxidative stress is in Alzheimer disease, it is likely that the process is highly dependent on redox-active transition metals such as iron and copper. Further investiga- tion into the role that oxidative stress mechanisms seem to play in the pathogenesis of Alzheimer disease may lead to novel clinical interventions. INTRODUCTION arguably the most important aspect of the degenerating phe- notype in AD-affected neurons. These inclusions largely con- Much of the research performed on Alzheimer disease sist of modified medium and high molecular weight neu- (AD) over the past decade has focused on oxidative stress rofilaments (NFM and NFH, respectively) as well as the mechanisms and its importance in disease pathogenesis. microtubule-stabilizing protein τ. In NFT, these two families Multiple lines of evidence have implicate