amelioratory effect of nanoconjugated vancomycin on spleen during vrsa-induced oxidative stressamelioratory nanoconjugated万古霉素对脾脏在vrsa-induced氧化应激的影响.pdfVIP

SAGE-Hindawi Access to Research Pathology Research International Volume 2011, Article ID 420198, 10 pages doi:10.4061/2011/420198 Research Article Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress Subhankari Prasad Chakraborty,1 Santanu KarMahapatra,1 Sumanta Kumar Sahu,2 Panchanan Pramanik,2 and Somenath Roy1 1 Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, West Bengal, Midnapore 721 102, India 2 Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, Kharagpur 721 302, India Correspondence should be addressed to Somenath Roy, sroy.vu@ Received 25 February 2011; Revised 27 April 2011; Accepted 10 May 2011 Academic Editor: Youhua Liu Copyright © 2011 Subhankari Prasad Chakraborty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. The aim of the present study was to evaluate the possible antioxidant effects of nanoconjugated vancomycin against VRSA infection on select makers of oxidative damage and antioxidant status in spleen. Methods. A coagulase-positive VRSA strain 6 was used for this study. VRSA infection was developed in Swiss mice by intraperitoneal injection of 5 × 10 CFU/mL bacterial solutions. VRSA-infected mice were treated with nanoconjugated vancomycin at its effective dose for 10 days. After decapitation, blood was used for determination of viable bacteria count an