ampk-dependent metabolic regulation by ppar agonistsampk-dependent代谢调节ppar激动剂.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2010, Article ID 549101, 10 pages doi:10.1155/2010/549101 Review Article AMPK-Dependent Metabolic Regulation by PPAR Agonists Woo Hyung Lee and Sang Geon Kim College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea Correspondence should be addressed to Sang Geon Kim, sgk@snu.ac.kr Received 22 April 2010; Accepted 25 June 2010 Academic Editor: Howard Glauert Copyright © 2010 W. H. Lee and S. G. Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ , and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels. It is noteworthy that PPARα or PPARγ agonists have pharmacological effects by modulating the activity of AMPK, which is a key cellular energy sensor. However, the role of AMPK in the metabolic effects of PPAR agonists has not been thoroughly focused. Moreover, AMPK activation by PPAR agonists seems to be independent of the receptor activation. This intriguing action of PPAR agonists may account in part for the mechanistic basis of the therapeutics in the treatment of metabolic disease. In this paper, the effects of PPAR agonists on metabolic functions were summarized with particular reference to their AMPK activity regulation. 1. Introduction components.