原创力文档amyloid beta peptide slows down sensory-induced hippocampal oscillationsβ淀粉样蛋白肽减慢sensory-induced海马振荡.pdfVIP
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amyloid beta peptide slows down sensory-induced hippocampal oscillationsβ淀粉样蛋白肽减慢sensory-induced海马振荡
Hindawi Publishing Corporation
International Journal of Peptides
Volume 2012, Article ID 236289, 8 pages
doi:10.1155/2012/236289
Research Article
Amyloid Beta Peptide Slows Down Sensory-Induced
Hippocampal Oscillations
˜ 1 ´ 1, 2
Fernando Pena-Ortega and Ramon Bernal-Pedraza
1 Departamento de Neurobiologıa del Desarrollo y Neurofisiologıa, Instituto de Neurobiologıa,
´ ´ ´
Universidad Nacional Autonoma de Mexico, UNAM-Campus Juriquilla, 76230 Juriquilla, QRO, Mexico
´ ´
2 Departamento de Farmacobiologıa, Cinvestav-IPN, Mexico City, DF, Mexico
´
˜
Correspondence should be addressed to Fernando Pena-Ortega, jfpena@unam.mx
Received 14 December 2011; Accepted 2 February 2012
Academic Editor: Ayman El-Faham
˜
Copyright © 2012 F. Pena-Ortega and R. Bernal-Pedraza. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
Alzheimer’s disease (AD) progresses with a deterioration of hippocampal function that is likely induced by amyloid beta (Aβ )
oligomers. Hippocampal function is strongly dependent on theta rhythm, and disruptions in this rhythm have been related to
the reduction of cognitive performance in AD. Accordingly, both AD patients and AD-transgenic mice show an increase in theta
rhythm at rest but a reduction in cognitive-induced
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