amyloid deposition in transplanted human pancreatic islets a conceivable cause of their long-term failure淀粉样蛋白沉积在人类胰岛细胞移植长期失败的一个可能的原因.pdfVIP
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amyloid deposition in transplanted human pancreatic islets a conceivable cause of their long-term failure淀粉样蛋白沉积在人类胰岛细胞移植长期失败的一个可能的原因
Hindawi Publishing Corporation
Experimental Diabetes Research
Volume 2008, Article ID 562985, 8 pages
doi:10.1155/2008/562985
Review Article
Amyloid Deposition in Transplanted Human Pancreatic Islets:
A Conceivable Cause of Their Long-Term Failure
1 1 ˚ 1 2
Arne Andersson, Sara Bohman, L. A. Hakan Borg, Johan F. Paulsson,
Sebastian W. Schultz,2 Gunilla T. Westermark,1, 2 and Per Westermark3
1 Department of Medical Cell Biology, Uppsala University, 751 23 Uppsala, Sweden
2 Division of Cell Biology, Diabetes Research Centre, Linkoping University, 581 83 Linkoping, Sweden
¨ ¨
3 Department Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden
Correspondence should be addressed to Arne Andersson, arne.andersson@mcb.uu.se
Received 28 March 2008; Revised 30 June 2008; Accepted 1 December 2008
Recommended by Steven E. Kahn
Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that,
more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the β -cell
function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that
amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It
is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure. The present paper
reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transpla
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