anti- -enolase antibodies in serum from pediatric patients affected by inflammatory diseases diagnostic and pathogenetic insights反烯醇酶抗体的血清儿科患者受炎性疾病诊断和发病的见解.pdfVIP

Hindawi Publishing Corporation International Journal of Rheumatology Volume 2011, Article ID 870214, 6 pages doi:10.1155/2011/870214 Clinical Study Anti-α-enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights Alessandra Pontillo,1 Nicola Di Toro,1 Paolo Edomi,2 A. Shadlow,3 A. Ammadeo,3 M. Gattorno,4 T. Not,3 L. Lepore,1 and S. Crovella3 1 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, via dell’Istria 65/1, 34137 Trieste, Italy 2 Department of Life Science, University of Trieste, Italy 3 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, and University of Trieste, via dell’Istria 65/1, 34137 Trieste, Italy 4 Pediatric Unit II, Institute of Child Health, IRCCS G. Gaslini, Genoa, Italy Correspondence should be addressed to Alessandra Pontillo, pontillo.a@ Received 7 June 2011; Accepted 9 August 2011 Academic Editor: Ruben Burgos-Vargas Copyright © 2011 Alessandra Pontillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Human glycolytic enzyme α-enolase was associated with human diseases and with inflammation. An ELISA test was developed to measure anti-α-enolase AAE IgG and AAE IgA in the serum from patients affected by inflammatory diseases with the purpose to evaluate it as a novel diagnostic marker. 80 healthy blood donors and 194 paediatric patients affected by Juvenile idiopathic arthritis (JIA), celiac disease (CD), Crohn’s Disease (CrD), hereditary periodic fever (HPF), and PFAPA syndrome were included in the study. HPF patients showed high levels of AAE antibodies, whereas JIA, CD, and CrD