antiamnesic activity of an ayurvedic formulation chyawanprash in miceantiamnesic活动的阿育吠陀配方chyawanprash老鼠.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 898593, 9 pages doi:10.1093/ecam/neq021 Original Article Antiamnesic Activity of an Ayurvedic Formulation Chyawanprash in Mice Milind Parle1 and Nitin Bansal1, 2 1 Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science Technology, Hisar 125001, India 2 Rajendra Institute of Technology Sciences, 4th milestone Hisar Road, Sirsa 125055, India Correspondence should be addressed to Milind Parle, mparle@rediff Received 20 April 2009; Accepted 1 March 2010 Copyright © 2011 M. Parle and N. Bansal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chyawanprash (Chy) is an ayurvedic formulation commonly consumed in Indian households. Chy is a comprehensive herbal tonic, prepared from around 50 herbs employing anwala (Emblica offi cinalis) as the basic ingredient. The present study was undertaken to explore the beneficial effects of Chy (at the dose of 1 and 2% w/w of diet) administered daily for 15 successive days in mice with memory deficits. A total of 228 mice divided in 38 groups were employed in this study. Morris water maze, Hebb- Williams maze and elevated plus maze served as exteroceptive memory models, whereas scopolamine (Sco)-induced amnesia and alprazolam (Alp)-induced amnesia served as interoceptive memory models. The brain acetylcholinesterase activity, brain thiobarbituric acid reactive substances (TBARS) and reduced glutathione levels (GSH) were also estimated. The administration of Chy for 15 consecutive days significantly