anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and -tocopherol presents in the extract of leaves of cissus sicyoides l. (vitaceae)类黄酮对小鼠抗焦虑和抗惊厥的影响,芳樟醇、生育酚的提取提出了叶子的白粉藤属sicyoides l .(葡萄科).pdfVIP

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anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and -tocopherol presents in the extract of leaves of cissus sicyoides l. (vitaceae)类黄酮对小鼠抗焦虑和抗惊厥的影响,芳樟醇、生育酚的提取提出了叶子的白粉藤属sicyoides l .(葡萄科).pdf

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anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and -tocopherol presents in the extract of leaves of cissus sicyoides l. (vitaceae)类黄酮对小鼠抗焦虑和抗惊厥的影响,芳樟醇、生育酚的提取提出了叶子的白粉藤属sicyoides l .(葡萄科)

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2009, Article ID 274740, 6 pages doi:10.1155/2009/274740 Research Article Anxiolytic and Anticonvulsant Effects on Mice of Flavonoids, Linalool, and α-Tocopherol Presents in the Extract of Leaves of Cissus sicyoides L. (Vitaceae) Edvaldo Rodrigues de Almeida,1 Krissia Rayane de Oliveira Rafael,1 Geraldo Bosco Lindoso Couto,2 and Ana Beatriz Matos Ishigami2 1 Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil 2 Department of Odontology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil Correspondence should be addressed to Edvaldo Rodrigues de Almeida, edvaldo.ra@ Received 6 September 2008; Revised 7 November 2008; Accepted 15 December 2008 Recommended by Omar Benzakour The aim of the present study is to demonstrate the anxiolytic and anticonvulsant eﬀects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed signiﬁcant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a signiﬁcant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a signiﬁcant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. e