automated diagnosis and treatment by lasers employing raman spectroscopy and catheter with optical fibers自动诊断和治疗由激光器采用拉曼光谱与光纤导管.pdfVIP

Spectroscopy 25 (2011) 147–154 147 DOI 10.3233/SPE-2011-0505 IOS Press Automated diagnosis and treatment by lasers employing Raman spectroscopy and catheter with optical fibers João Carlos Lázaro a , Alderico Rodrigues de Paula Jr. a , Leonardo Marmo Moreira b,∗, Juliana Pereira Lyon c , Marcos Tadeu T. Pacheco d and Carlos José de Lima d a Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, São Paulo, Brazil b Departamento de Engenharia de Biossistemas, Universidade Federal de São João Del Rei, São João Del Rei, Minas Gerais, Brazil c Departamento de Ciências Naturais, Universidade Federal de São João Del Rei, São João Del Rei, Minas Gerais, Brazil d Instituto de Engenharia Biomédica, Universidade Camilo Castelo Branco, São José dos Campos, São Paulo, Brazil Abstract. Raman spectroscopy is considered a very powerful tool for biochemical characterization, especially regarding bio- logical samples. This technique allows the diagnosis of several diseases, such as cancer and atherosclerosis. In this context, the non invasive or minimally invasive character of the spectroscopic resources is an auspicious clinical advancement when compared with conventional procedures, which are associated to significant trauma and possible decrease in the quality of life of patients. Recently, the use of catheter with optical fibers associated to Raman spectroscopy has significantly minimized the invasive character of several clinical procedures. It is important to notice that this optical sensor already presents flexibility due to the employment of optical fibers to applications of lasers. Nowadays, this kind of device possesses autonomy of use and can be coupled to an optic fiber in order to permit the treatment with lasers. In this way, it is possible to develop an electronic auto- mated optic system that achieves a diagnosis thr