assessment of wound healing activity of the aqueous extracts of colutea cilicica boiss. bal. fruits and leaves伤口愈合的评估活动的水提取物colutea cilicica木香。.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 758191, 7 pages doi:10.1093/ecam/nep190 Original Article Assessment of Wound Healing Activity of the Aqueous Extracts of Colutea cilicica Boiss. Bal. Fruits and Leaves ¨ 1 1 ¨ 1 2 2 Ipek Pes¸in Suntar, Ufuk Koca, Esra Kupeli Akkol, Demet Yılmazer, and Murat Alper 1 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey 2 Department of Pathology, Dıs¸kapı Yıldırım Beyazit Education and Research Hospital, Ankara, Turkey ¨ Correspondence should be addressed to Esra Kupeli Akkol, esrak@.tr Received 16 July 2009; Accepted 19 October 2009 ¨ Copyright © 2011 Ipek Pes¸in Suntar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The fruiting branches of Colutea cilicica Boiss. Bal., along with leaves and fruits, have been used to heal inflammatory wounds at traditional medicine in various parts of Turkey. In order to evaluate the wound healing activity of the plant, aqueous extracts were prepared from the flowering parts and fruits of Colutea cilicica Boiss. Bal. by using 40◦C distilled water. Incision wound healing models by using tensiometer on rats and excision wound healing models on mice were employed to assess the activity. Significant wound healing activity was observed when ointment formula