association between agnors and immunohistochemical expression of er, pr, her2neu, and p53 in breast carcinomaagnors之间的联系和免疫组织化学表达er,pr,her2neu,p53在乳房癌.pdfVIP

SAGE-Hindawi Access to Research Pathology Research International Volume 2011, Article ID 237217, 6 pages doi:10.4061/2011/237217 Research Article Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2/neu, and p53 in Breast Carcinoma Hussain Gadelkarim Ahmed,1, 2 Mohammed Ali Al-Adhraei,3 and Ibraheem M. Ashankyty4 1 Department of Pathology, College of Medicine, Hail University, Hail, Saudi Arabia 2 Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum 11111, Sudan 3 National Oncology Center, Al-Jumhori Teaching Hospital, Sana’a, Yemen 4 Faculty of Applied Science, Hail University, Hail, Saudi Arabia Correspondence should be addressed to Hussain Gadelkarim Ahmed, hussaingad1972@ Received 21 June 2011; Accepted 26 August 2011 Academic Editor: Qian Peng Copyright © 2011 Hussain Gadelkarim Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Settings. Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins) for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions. Methodology. The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, HER2/neu, and p53 in breast carcinoma in serial paraffin sections from 137 breast carcinomas. Twenty control cases of benign breast lesions were included. Results. Mean AgNOR counts correlated significantly inversely with hormone estrogen receptors (ER), Progesterone receptors (PR), and p53 immunohistoc