association between habitual dietary salt intake and risk of gastric cancer a systematic review of observational studies习惯性膳食盐摄入量与胃癌风险观察性研究的系统评价.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2012, Article ID 808120, 11 pages doi:10.1155/2012/808120 Research Article Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies Sheng Ge, Xiaohui Feng, Li Shen, Zhanying Wei, Qiankun Zhu, and Juan Sun Department of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China Correspondence should be addressed to Sheng Ge, gesheng607@126.com Received 20 April 2012; Accepted 11 June 2012 Academic Editor: Jin-Lian Chen Copyright © 2012 Sheng Ge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer. Methods. Case-control studies and cohort studies published between January 1992 and January 2012 on PubMed and Embase were searched. We quantified associations between salt intake and gastric cancer with meta-analysis. Results. Eleven studies (7 case controls and 4 cohorts) finally were included in the meta-analysis (total population: n = 2076498; events: n = 12039). The combined odds ratio showed significantly positive association between high salt intake and gastric cancer com- pared with low salt intake (OR = 2.05, 95% CI [1.60, 2.62]; P 0.00001). In subgroup meta-analysis, findings were slightly different when analyses were restricted to salty food intak