bacterial isolates and antibiotic sensitivity among gambian children with severe acute malnutrition细菌分离和抗生素敏感性在冈比亚严重急性营养不良的儿童.pdfVIP

Hindawi Publishing Corporation International Journal of Pediatrics Volume 2011, Article ID 825123, 8 pages doi:10.1155/2011/825123 Clinical Study Bacterial Isolates and Antibiotic Sensitivity among Gambian Children with Severe Acute Malnutrition Uduak A. Okomo,1 Danlami Garba,1 Augustin E. Fombah,1 Ousman Secka,1 Usman N. A. Ikumapayi,1 Jacob. J. Udo,2 and Martin O. C. Ota1 1 Medical Research Council (UK) Laboratories, Atlantic Road, Fajara, P.O. Box 273, Banjul, Gambia 2 Department of Paediatrics, University of Calabar teaching Hospital, PMB 1278, Calabar, Cross River State, Nigeria Correspondence should be addressed to Uduak A. Okomo, uokomo@mrc.gm Received 31 March 2011; Accepted 19 May 2011 Academic Editor: Sunit C. Singhi Copyright © 2011 Uduak A. Okomo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Establishing the pattern of infection and antimicrobial sensitivities in the local environment is critical to rational use of antibiotics and the development of management algorithms. Methods. Morbidity history and physical examination of 140 children with severe acute malnutrition were recorded. Their blood, stool, and urine samples were cultured and antibiotic sensitivity patterns determined for any bacterial pathogens isolated. Results. Thirty-eight children had a pathogen isolated from blood culture, 60% of which were considered contaminants. Coagulase negative staphylococcus was the predominant contaminant, while the major causes of bacteraemia were nontyphoidal Salmonella (13%), S. pneumoniae (10%), and E. coli (8%). E. coli accounted for 58% of the u