atherosclerosis and thrombosis insights from large animal models动脉粥样硬化和血栓形成的见解从大型动物模型.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 907575, 12 pages doi:10.1155/2011/907575 Review Article Atherosclerosis and Thrombosis: Insights from Large Animal Models Gemma Vilahur,1, 2 Teresa Padro,1, 2 and Lina Badimon1, 2, 3 1 Cardiovascular Research Center (CSIC-ICCC), Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08025 Barcelona, Spain 2 CIBERobn, Barcelona, Spain 3 Autonomous University of Barcelona (UAB), Barcelona, Spain Correspondence should be addressed to Lina Badimon, lbadimon@csic-iccc.org Received 23 September 2010; Accepted 9 December 2010 Academic Editor: Oreste Gualillo Copyright © 2011 Gemma Vilahur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well- reported species-related differences. This paper provides an overview of the available ath