原创力文档arterial stiffness in chronic kidney disease the usefulness of a marker of vascular damage动脉硬化在慢性肾脏疾病的有用性血管损伤的一个标志.pdfVIP
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arterial stiffness in chronic kidney disease the usefulness of a marker of vascular damage动脉硬化在慢性肾脏疾病的有用性血管损伤的一个标志
SAGE-Hindawi Access to Research
International Journal of Nephrology
Volume 2011, Article ID 734832, 5 pages
doi:10.4061/2011/734832
Review Article
Arterial Stiffness in Chronic Kidney Disease: The Usefulness of
a Marker of Vascular Damage
Antonio Bellasi,1 Emiliana Ferramosca,1 and Carlo Ratti2
1 Division of Nephrology, S.Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
2 Division of Cardiology, Ospedale di Mirandola, 41121 Modena, Italy
Correspondence should be addressed to Antonio Bellasi, antoniobellasi@
Received 23 March 2011; Accepted 27 March 2011
Academic Editor: Biagio Raffaele Di Iorio
Copyright © 2011 Antonio Bellasi et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Increased arterial stiffness is a marker of vasculopathy in chronic kidney disease (CKD) patients, suggesting a significant
cardiovascular damage. Detection of arterial stiffness provides physicians with useful prognostic information independent of
traditional cardiovascular (CV) risk factors. In addition, this knowledge may help guide appropriate therapeutic choices and
monitor the effectiveness of antihypertensive therapies. We review the relationship between arterial stiffness and CKD, as well as
the prognostic implications of increased arterial stiffness and the potential therapeutic strategies to ameliorate arterial compliance
and outcome in CKD.
1. Introduction in combination with traditional CV risk factors to assess
the CV risk of a single individual. Indeed, a
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