antioxidant stress and anti-inflammation of pparα on warm hepatic ischemia-reperfusion injury抗氧化压力和抗炎的pparα温暖肝缺血再灌注损伤.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2012, Article ID 738785, 8 pages doi:10.1155/2012/738785 Review Article Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury Zhixin Gao and Yuan-Hai Li Department of Anesthesiology, First Affi liated Hospital of Anhui Medical University, Hefei 230022, China Correspondence should be addressed to Yuan-Hai Li, liyuanhai-1@163.com Received 25 July 2012; Revised 27 September 2012; Accepted 10 October 2012 Academic Editor: Yasuteru Kondo Copyright © 2012 Z. Gao and Y.-H. Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury. 1. Introduction to perform complex procedures such as large liver resections and repairs that otherwise would have resulted in massive Hepatic ischemia reperfusion (IR) injury is an important