原创力文档antispasmodic and antidiarrheal activities of valeriana hardwickii wall. rhizome are putatively mediated through calcium channel blockade缬草的抗痉挛药和止泻的活动hardwickii墙。.pdfVIP
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antispasmodic and antidiarrheal activities of valeriana hardwickii wall. rhizome are putatively mediated through calcium channel blockade缬草的抗痉挛药和止泻的活动hardwickii墙。
Hindawi Publishing Corporation
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 304960, 6 pages
doi:10.1155/2011/304960
Research Article
Antispasmodic and Antidiarrheal Activities of
Valeriana hardwickii Wall. Rhizome Are Putatively
Mediated through Calcium Channel Blockade
Samra Bashir,1, 2 Raafia Memon,1 and Anwar H. Gilani1
1 Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
2 Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Correspondence should be addressed to Anwar H. Gilani, anwar.gilani@
Received 21 May 2010; Revised 13 December 2010; Accepted 10 January 2011
Copyright © 2011 Samra Bashir et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Valeriana hardwickii is indigenous to Pakistan, Burma and Ceylon, where it is traditionally being used as an antispasmodic
and antidiarrheal, besides its culinary use as spice. The aim of this paper was to provide pharmacological validation to these
medicinal uses. The crude aqueous-methanolic extract of Valeriana hardwickii rhizome (Vh.Cr) was studied on isolated rabbit
jejunum and castor oil-induced diarrhea in mice for spasmolytic and antidiarrheal properties, respectively. Vh.Cr caused
concentration-dependent (0.01–1 mg/mL) relaxation of spontaneous contractions in isolated rabbit jejunum and inhibited K+ -
induced contractions (0.01–0.3 mg/mL), similar to verapamil, suggestive of calcium channel blockade (CCB). The CCB effect was
confirmed when pretreatment of the jejunum preparations with Vh.Cr produced a concentration-dependent (0.03–0.1 m
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