antitumor activities of kushen literature reviewkushen文献综述抗肿瘤活性.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 373219, 11 pages doi:10.1155/2012/373219 Review Article Antitumor Activities of Kushen: Literature Review Mingyu Sun,1, 2, 3 Hongyan Cao,1 Lin Sun,4 Shu Dong,1 Yanqin Bian,1 Jun Han,5 Lijun Zhang,1 Shuang Ren,1 Yiyang Hu,1, 2, 3 Chenghai Liu,1, 2, 3 Lieming Xu,1, 2, 3 and Ping Liu1, 2, 3 1 Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China 2 Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China 3 E-institute of Shanghai Municipal Education Commission, Shanghai 201203, China 4 Liaoning University of Traditional Chinese Medicine, Shenyang 100032, China 5 School of Pharmacy, Second Military Medical University, Shanghai 201203, China Correspondence should be addressed to Mingyu Sun, mysun248@ and Ping Liu, liuliver@ Received 4 January 2012; Revised 30 May 2012; Accepted 7 June 2012 Academic Editor: Francesca Borrelli Copyright © 2012 Mingyu Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS- As) an