antirheumatoid arthritis activities and chemical compositions of phenolic compounds-rich fraction from urtica atrichocaulis, an endemic plant to chinaantirheumatoid关节炎活动和化学成分的酚醛compounds-rich分数荨麻属atrichocaulis,中国的特有植物.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 818230, 10 pages doi:10.1155/2012/818230 Research Article Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China Mengyue Wang,1 Ke Li,1 Yuxiao Nie,1 Yingfang Wei,2 and Xiaobo Li1 1 School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China 2 School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China Correspondence should be addressed to Xiaobo Li, xbli@ Received 25 April 2011; Revised 20 June 2011; Accepted 29 June 2011 Academic Editor: Ann Gill Taylor Copyright © 2012 Mengyue Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Urtica atrichocaulis, an endemic plant to China, is commonly used to treat rheumatoid arthritis even though its pharmaceutical activities and chemical constituents were not studied. Herein, we reported our investigations on the chemical compositions of the phenolic compounds-rich fraction from U. atrichocaulis (TFUA) and their antirheumatoid arthritis activities. We found that the TFUA significantly inhibited the adjuvant-induced rats arthritis, carrageenin-induced rats paw edema, cotton pellet-induced mice granuloma, and the acetic acid-induced mice writhing response. Our phytochemical investigations on the TFUA resulted in the first-time isolation and identification of 17 phenolic constituents and a bis (5-formylfurfuryl) ether. The extensive HPLC analysis also revealed the chemical compositions of TFUA. Our furt