anti-stress and adaptogenic activity of l-arginine supplementation抗应激和adaptogenic活动补充精氨酸.pdfVIP

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anti-stress and adaptogenic activity of l-arginine supplementation抗应激和adaptogenic活动补充精氨酸.pdf

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anti-stress and adaptogenic activity of l-arginine supplementation抗应激和adaptogenic活动补充精氨酸

Advance Access Publication 8 December 2004 eCAM 2005;2(1)93–97 doi:10.1093/ecam/neh054 Original Article Anti-stress and Adaptogenic Activity of L-Arginine Supplementation Vanita Gupta, Asheesh Gupta, Shalini Saggu, Harish M. Divekar, S. K. Grover and Ratan Kumar Department of Biochemistry, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Delhi 110 054, India In the present study, oral supplementation of L-arginine in rats was evaluated for its anti-stress and adaptogenic activity using the cold (5C)–hypoxia (428 mmHg)–restraint (C-H-R) animal model. A dose-dependent study of L-arginine was carried out at doses of 12.5, 25.0, 50.0, 100.0, 200.0 and 500.0 mg/kg body weight, administered orally 30 min prior to C-H-R exposure. The time taken by the rat to attain a rectal temperature of 23C (Trec 23C) during C-H-R exposure and its recovery to Trec 37C at normal atmospheric pressure and 32 1C were used as biomarkers of anti-stress and adaptogenic activity. Biochemical parameters related to lipid peroxidation, anti-oxidants, cell membrane permeabil- ity, nitric oxide and stress, with and without administration of the least effective L-arginine dose, were measured in rats on attaining Trec 23C and Trec 37C. The least effective adaptogenic dose of L-arginine was 100.0 mg/kg body weight. The C-H-R exposure of control rats, on att