arterial stiffness and dialysis calcium concentration动脉硬化和透析钙浓度.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 839793, 6 pages doi:10.4061/2011/839793 Review Article Arterial Stiffness and Dialysis Calcium Concentration ´ Fabrice Mac-Way, Amelie Leboeuf, and Mohsen Agharazii Division of Nephrology and Research Center of CHUQ, L’Hotel Dieu de Quebec Hospital and Faculty of Medicine, ˆ ´ Laval University, Quebec, QC, Canada G1R 2J6 Correspondence should be addressed to Mohsen Agharazii, mohsen.agharazii@crhdq.ulaval.ca Received 31 October 2010; Accepted 2 March 2011 Academic Editor: Biagio Raffaele Di Iorio Copyright © 2011 Fabrice Mac-Way et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workload and decreased myocardial perfusion. Although the clinical consequence of aortic stiffness has been clearly established, its pathophysiology in various clinical conditions still remains poorly understood. The aim of the present paper is to review the studies that have looked at the impact of dialysis calcium concentration on arterial stiffness. Overall, the results of small short-term studies sugg