assessing cerebrovascular reactivity in carotid steno-occlusive disease using mri bold and asl techniques评估脑血管反应性颈动脉steno-occlusive疾病使用mri大胆和asl技术.pdfVIP

Hindawi Publishing Corporation Radiology Research and Practice Volume 2012, Article ID 268483, 10 pages doi:10.1155/2012/268483 Review Article Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques Renata F. Leoni,1 Kelley C. Mazzetto-Betti,1 Afonso C. Silva,2 Antonio C. dos Santos,1 Draulio B. de Araujo,3, 4 ˜ 1 1 Joao P. Leite, and Octavio M. Pontes-Neto 1 Department of Neuroscience and Behavioral Sciences, FMRP, University of Sao Paulo, Ribeirao Preto, SP 14049-900, Brazil 2 Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA 3 Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, RN 59012-300, Brazil 4 Brain Institute, Federal University of Rio Grande do Norte, Natal, RN 59020-130, Brazil Correspondence should be addressed to Octavio M. Pontes-Neto, ompneto@usp.br Received 10 February 2012; Revised 17 April 2012; Accepted 17 April 2012 Academic Editor: Kyousuke Kamada Copyright © 2012 Renata F. Leoni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and arterial spin labeling (ASL), have emerged as promising noninvasive tools to evaluate altered CVR with whole-brain coverage,