bayesian functional data clustering for temporal microarray data贝叶斯功能数据时序微阵列数据的聚类.pdfVIP

Hindawi Publishing Corporation International Journal of Plant Genomics Volume 2008, Article ID 231897, 4 pages doi:10.1155/2008/231897 Research Article Bayesian Functional Data Clustering for Temporal Microarray Data Ping Ma,1 Wenxuan Zhong,1 Yang Feng,1 and Jun S. Liu2 1 Department of Statistics, University of Illinois, Champaign, IL 61820, USA 2 Department of Statistics, Harvard University, Cambridge, MA 02138, USA Correspondence should be addressed to Ping Ma, pingma@ and Jun S. Liu, jliu@ Received 24 July 2007; Accepted 18 December 2007 Recommended by Nengjun Yi We propose a Bayesian procedure to cluster temporal gene expression microarray profiles, based on a mixed-effect smoothing- spline model, and design a Gibbs sampler to sample from the desired posterior distribution. Our method can determine the cluster number automatically based on the Bayesian information criterion, and handle missing data easily. When applied to a microarray dataset on the budding yeast, our clustering algorithm provides biologically meaningful gene clusters according to a functional enrichment analysis. Copyright © 2008 Ping Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION the results of gene expression clustering in temporal data. It is also possible to use an autoregression model to describe the Microarray technology enables the scientist to measure the gene expression time series, but such a model often requires mRNA expression levels of thousands of g