attenuation of diabetic nephropathy in otsuka long-evans tokushima fatty (oletf) rats with a combination of chinese herbs (tangshen formula)糖尿病肾病的衰减大冢long-evans德岛脂肪(oletf)老鼠的联合中药(党参公式).pdfVIP

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attenuation of diabetic nephropathy in otsuka long-evans tokushima fatty (oletf) rats with a combination of chinese herbs (tangshen formula)糖尿病肾病的衰减大冢long-evans德岛脂肪(oletf)老鼠的联合中药(党参公式).pdf

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attenuation of diabetic nephropathy in otsuka long-evans tokushima fatty (oletf) rats with a combination of chinese herbs (tangshen formula)糖尿病肾病的衰减大冢long-evans德岛脂肪(oletf)老鼠的联合中药(党参公式)

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 613737, 8 pages doi:10.1155/2011/613737 Research Article Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula) Haojun Zhang,1 Ping Li,1 Frank J. Burczynski,2 Yuewen Gong,2 Patrick Choy,3 Hong Sha,1 and Jing Li4 1 Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, No. 2 Yinghua Dongjie, Hepingli, Beijing 100029, China 2 Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5 3 Faculty of Medicine, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5 4 Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Hai Yun Cang, Dongcheng District, Beijing 100700, China Correspondence should be addressed to Ping Li, lp8675@ Received 21 July 2010; Revised 22 November 2010; Accepted 13 December 2010 Copyright © 2011 Haojun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetic nephropathy is one of the most signiﬁcant microvascular complications in patients with type 2 diabetics. The concise mechanism of diabetic nephropathy is unknown and there is no successful treatment. The objective of study was to investigate eﬀects of Chinese herbs (Tangshen Formula) on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. OLETF rats and LETO rats were divided into four groups: LETO control, OLETF diabetics, OLETF diabetics treated with Tangshen