atypical febrile seizures, mesial temporal lobe epilepsy, and dual pathology非典型发热性癫痫、内侧颞叶癫痫和双重病理学.pdfVIP

Hindawi Publishing Corporation Epilepsy Research and Treatment Volume 2012, Article ID 342928, 9 pages doi:10.1155/2012/342928 Review Article Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology 1 ´ 1, 2 1, 2 Nathalie T. Sanon, Sebastien Desgent, and Lionel Carmant 1 Departement de Pediatrie, Centre de Recherche du Centre Hospitalier Universitaire (CHU) Sainte-Justine, Universite de Montreal, ´ ´ ´ ´ Montreal, QC, Canada H3T 1C5 ´ 2 Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada H3C 3J7 ´ ´ ´ ´ ´ ´ Correspondence should be addressed to Lionel Carmant, lionel.carmant@umontreal.ca Received 25 December 2011; Revised 2 February 2012; Accepted 7 February 2012 Academic Editor: Seyed M. Mirsattari Copyright © 2012 Nathalie T. Sanon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Febrile seizures occurring in the neonatal period, especially when prolonged, are thought to be involved in the later development of mesial temporal lobe epilepsy (mTLE) in children. The presence of an often undetected, underlying cortical malformation has also been reported to be implicated in the epileptogenesis process following febrile seizures. This paper highlights some of the various animal models of feb