behavioral, neurochemical and neuroendocrine effects of abnormal savda munziq in the chronic stress mice行为、神经化学和神经内分泌的影响异常savda munziq慢性压力的老鼠.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 426757, 8 pages doi:10.1155/2012/426757 Research Article Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice Nurmuhammat Amat,1 Parida Hoxur,2 Dang Ming,1 Aynur Matsidik,1 Anake Kijjoa,3 and Halmurat Upur1 1 Traditional Uighur Medicine Department, Xinjiang Medical University, 393 Medical University Road, Urumqi, Xinjiang 830011, China 2 Neurology Department, Xinjiang Medical University Affi liation of Traditional Chinese Medicine Hospital, 116 Huanghe Road, Urumqi, Xinjiang 83000, China 3 Instituto de Ciencias Biomedicas de Abel Salazar (ICBAS), Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, ˆ ´ 40-50-313 Porto, Portugal Correspondence should be addressed to Halmurat Upur, halmurat@263.net Received 6 April 2012; Revised 1 June 2012; Accepted 18 June 2012 Academic Editor: Paul Siu-Po Ip Copyright © 2012 Nurmuhammat Amat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH),