原创力文档beneficial effect of brewers yeast extract on daily activity in a murine model of chronic fatigue syndrome有益的影响啤酒的酵母提取物在日常活动的小鼠模型慢性疲劳综合症.pdfVIP
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beneficial effect of brewers yeast extract on daily activity in a murine model of chronic fatigue syndrome有益的影响啤酒的酵母提取物在日常活动的小鼠模型慢性疲劳综合症
Advance Access Publication 23 January 2006 eCAM 2006;3(1)109–115
doi:10.1093/ecam/nek012
Original Article
Beneficial Effect of Brewers’ Yeast Extract on Daily Activity in a
Murine Model of Chronic Fatigue Syndrome
1 1 1 1 4
Takashi Takahashi , Fei Yu , Shi-jie Zhu , Junji Moriya , Hiroyuki Sumino ,
Shigeto Morimoto2, Nobuo Yamaguchi3 and Tsugiyasu Kanda1
1Department of General Medicine, 2 Department of Geriatric Medicine and 3Department of Serology,
Kanazawa Medical University, Ishikawa, Japan and 4 Department of Medicine and Biological Science,
Gunma University Graduate School of Medicine, Gunma, Japan
The aim of this study was to assess the effect of Brewers’ yeast extract (BYE) on daily activity in a
mouse model of chronic fatigue syndrome (CFS). CFS was induced by repeated injection of Brucella
abortus (BA) antigen every 2 weeks. BYE was orally administered to mice in a dose of 2 g per kg per
day for 2 weeks before injecting BA and for 4 weeks thereafter. We evaluated daily running activity
in mice receiving BYE as compared with that in untreated mice. Weekly variation of body weight
(BW) and survival in both groups was monitored during the observation period. Spleen weight (SW),
SW/BW ratio, percent splenic follicular area and expression levels of interferon-g (IFN-g ) and
interleukin-10 (IL-10) mRNA in spleen were determined in both groups at the time of sacrifice. The
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