biomarkers of adverse response to mercury histopathology versus thioredoxin reductase activity生物标记物的不良应对汞组织病理学和硫氧还蛋白还原酶活性.pdfVIP

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biomarkers of adverse response to mercury histopathology versus thioredoxin reductase activity生物标记物的不良应对汞组织病理学和硫氧还蛋白还原酶活性.pdf

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biomarkers of adverse response to mercury histopathology versus thioredoxin reductase activity生物标记物的不良应对汞组织病理学和硫氧还蛋白还原酶活性

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 359879, 9 pages doi:10.1155/2012/359879 Research Article Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase Activity 1, 2 3 ˜ ´ 2 4 Vasco Branco, Paula Ramos, Joao Canario, Jun Lu, Arne Holmgren,4 and Cristina Carvalho1 1 Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenue Professor Gama Pinto, 1649-003 Lisbon, Portugal 2 Marine Environment and Biodiversity Unit, Institute for Sea and Atmospheric Research (IPIMAR/IPMA), Avenue Brasılia, 1440-006 Lisbon, Portugal ´ 3 Aquaculture Unit, Institute for Sea and Atmospheric Research (IPIMAR/IPMA), Avenue Brasılia, 1440-006 Lisbon, Portugal ´ 4 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden Correspondence should be addressed to Cristina Carvalho, cristina.carvalho@ﬀ.ul.pt Received 20 April 2012; Accepted 25 May 2012 ˜ Academic Editor: Joao B.T. Rocha Copyright © 2012 Vasco Branco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Exposure to mercury is normally assessed by measuring its accumulation in hair, blood or urine. Currently, the biomarkers of eﬀect that have been proposed for mercurials, such as coproporphyrines or oxidative stress mar