brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice脑源性神经营养因子调节能量消耗通过肥胖糖尿病小鼠的中枢神经系统.pdfVIP

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brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice脑源性神经营养因子调节能量消耗通过肥胖糖尿病小鼠的中枢神经系统.pdf

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brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice脑源性神经营养因子调节能量消耗通过肥胖糖尿病小鼠的中枢神经系统

Int. Jnl. Experimental Diab. Res., Vol. 2, pp. 201-209 (C) 2001 OPA (OverseasPublishers Association) N.V. Reprints available directly from the publisher Published by license under Photocopying permitted by license only the HarwoodAcademic Publishers imprint, part of Gordon and Breach Publishing, member of the Taylor Francis Group. Printed in the U.S.A. Brain-derived Neurotrophic Factor Regulates Energy Expenditure Through the Central Nervous System in Obese Diabetic Mice TAKESHI NONOMURAa, ATSUSHI TSUCHIDAa, MICHIKO ONO-KISHINOa, TSUTOMUNAKAGAWAa, MUTSUO TAIJIa’* and HIROSHI NOGUCHIa,b aSumitomo Pharmaceuticals Co. Ltd., Discovery Research Laboratories II, 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-0022, Japan; bSumitomo Pharmaceuticals Co. Ltd., Business Development and Licensing Office, 3-11 Kandasurugadai, Chiyoda-ku, Tokyo 101-8319, Japan (Received2 April 2001; Revised 29 June 2001; Infinal form 30 July 2001) It has been previously demonstrated that brain- INTRODUCTION derived neurotrophic factor (BDNF) regulates glu- cose metabolism and energy expenditure in rodent diabetic models such as C57BL/KsJ-leprdb/leprab Brain-derived neurotrophic factor (BDNF), a (db/db) mice. Central administration of BDNF has member of the neurotrophin family, has been been found to reduce blood glucose in db/db mice, widely demonstrated to function in the central suggesting that BDNF acts through the central nerv- and