brown adipose tissue can be activated or inhibited within an hour before 18f-fdg injection a preliminary study with micropet褐色脂肪组织可以激活或抑制在一个小时前18 f-fdg注入micropet的初步研究.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 159834, 5 pages doi:10.1155/2011/159834 Research Article Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection: A Preliminary Study with MicroPET Chenxi Wu, Wuying Cheng, Haiqun Xing, Yonghong Dang, Fang Li, and Zhaohui Zhu Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Correspondence should be addressed to Zhaohui Zhu, zzh 1969@ Received 30 December 2010; Accepted 16 February 2011 Academic Editor: Mei Tian Copyright © 2011 Chenxi Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Brown adipose tissue (BAT) is emerging as a potential target for treating human obesity. It has been indicated that BAT is rich in innervations of sympathetic nerve control. Using 18F-FDG microPET imaging, this study aims at evaluating how factors related to sympathetic activation/inhibition changed BAT metabolism of mice. BAT 18F-FDG uptake were semiquantitatively evaluated in different groups of mice under temperature (cold or warm stimulus) or pharmacological interventions (norepinephrine, epinephrine, isoprenaline, or propranolol) and were compared with the corresponding controls. It was found that BAT activation can be stimulated by cold exposure (P = 1.96 × 10−4 ), norepinephrine (P = .002), or both (P = 2.19 × 10−6 ) within an hour before 18F-FDG injection and can also be alleviated by warming up (P = .001) or propranolol lavage (P = .027). This preliminary study