tyrosine kinase signaling in kidney glomerular podocytes肾脏肾小球足细胞中酪氨酸激酶信号传导等.pdf

Hindawi Publishing Corporation Journal of Signal Transduction Volume 2011, Article ID 317852, 10 pages doi:10.1155/2011/317852 Review Article Tyrosine Kinase Signaling in Kidney Glomerular Podocytes Seisuke Hattori,1 Shoichiro Kanda,2 and Yutaka Harita2, 3, 4 1 Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan 2 Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan 3 Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan 4 Division of Functional Proteomics, Graduate School of Nanobioscience, Yokohama City University Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Correspondence should be addressed to Seisuke Hattori, hattoris@pharm.kitasato-u.ac.jp Received 21 January 2011; Revised 17 March 2011; Accepted 30 March 2011 ´ ´ Academic Editor: J. Adolfo Garcıa-Sainz Copyright © 2011 Seisuke Hattori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. During the last decade, several key molecules have been identified as essential components for the filtration barrier function of kidney glomerular podocytes. Mutations in genes encoding these molecules severely impair the podocyte architecture in the affected patients, leading to the development of proteinuria. Extensive investigations have been performed on the function of these molecules, which highlights the importance of tyrosine kinase signaling in the podocytes. An Src family tyrosi