tyrosine phosphorylation-mediated signaling pathways in dictyostelium在盘基网柄菌酪氨酸phosphorylation-mediated信号通路.pdf

Hindawi Publishing Corporation Journal of Signal Transduction Volume 2011, Article ID 894351, 7 pages doi:10.1155/2011/894351 Review Article Tyrosine Phosphorylation-Mediated Signaling Pathways in Dictyostelium Tong Sun and Leung Kim Department of Biological Sciences, Florida International University, Miami, FL 33199, USA Correspondence should be addressed to Leung Kim, kiml@fi Received 27 December 2010; Accepted 21 February 2011 ´ ´ Academic Editor: J. Adolfo Garcıa-Sainz Copyright © 2011 T. Sun and L. Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. While studies on metazoan cell proliferation, cell differentiation, and cytokine signaling laid the foundation of the current paradigms of tyrosine kinase signaling, similar studies using lower eukaryotes have provided invaluable insight for the understanding of mammalian pathways, such as Wnt and STAT pathways. Dictyostelium is one of the leading lower eukaryotic model systems where stress-induced cellular responses, Wnt-like pathways, and STAT-mediated pathways are well investigated. These Dictyostelium pathways will be reviewed together with their mammalian counterparts to facilitate the comparative understanding of these variant and noncanonical pathways. 1. Introduction gsk3 − cells, and GSK3 kinase activity was compromised with the concomitant reduction of tyrosine 214 phosphorylation Studies on the tyrosine phosphorylation of Dictyostelium