type i diabetes-associated tolerogenic properties of interleukin-2i型糖尿病危害耐受性白介素2的性质.pdf

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 289343, 9 pages doi:10.1155/2011/289343 Review Article Type I Diabetes-Associated Tolerogenic Properties of Interleukin-2 Aziz Alami Chentoufi,1 Simon Gaudreau,2 Alex Nguyen,3 Mahmoud Sabha,4 Abdelaziz Amrani,2 and Geyhad ElGhazali1, 5 1 Department of Immunology, Faculty of Medicine, King Fahad Medical City, Riyadh 11 525, P.O. Box 59046, Saudi Arabia 2 Immunology Division, Department of Paediatric, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4 3 Faculty of Medicine, Touro University Nevada, Henderson, NV 89014, USA 4 Faculty of Medicine, St. George’s University, Bay Shore, NY 11706, USA 5 Faculty of Medicine and Medical Sciences, University of Shendi, Sudan Correspondence should be addressed to Aziz Alami Chentoufi, chentoufiaziz@ Received 15 January 2011; Accepted 8 March 2011 Academic Editor: V. Geenen Copyright © 2011 Aziz Alami Chentoufi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Type 1 Diabetes (T1D) results from insulin-producing beta cells destruction by diabetogenic T lymphocytes in humans and nonobese diabetic (NOD) mice. The breakdown of tolerance has been associated with a defect in the number and the function of naturally occurring regulatory T cells (nTreg) that are the master player in peripheral tolerance. Gene knockout experiments in mouse models have shown a nonredundant activity of IL-2 related to its critical role in inducing nTreg and controlling peripheral T cell tolerance. Whereas