renal functional mri in mice evaluated with a dual bolus of intravascular and diffusible contrast agents小鼠的肾脏功能磁共振成像评估血管内的双丸和扩散性的造影剂.pdf

J. Biomedical Science and Engineering, 2011, 4, 315-319 JBiSE doi:10.4236/jbise.2011.44041 Published Online April 2011 (http://www.SciRP.org/journal/jbise/). Renal functional MRI in mice evaluated with a dual bolus of intravascular and diffusible contrast agents Michael Pedersen1 2 3 2 , Sukru Oguz Topcu , Steven Sourbron , Rikke Nørregaard 1MR Research Center, University of Aarhus, Skejby, Denmark; 2Institute of Clinical Medicine, University of Aarhus, Skejby, Denmark; 3Division of Medical Physics, Leeds University Hospital, Leeds, Great Britain. Email: michael@mr.au.dk Received 15 February 2011; revised 12 March 2011; accepted 14 March 2011. ABSTRACT are small particles having a vascular remanence and are taken up by the macrophages. Consequently, USPIOs Background: The aim of this study was to evaluate have a low clearance, facilitated mainly by the Kupffer the feasibility of a dual-bolus protocol, where a first cells, resulting in a relatively large mean half-life (sev- bolus of an intravascular tracer is used to measure eral hours in humans). This pharmacokinetic behaviour perfusion, followed by a second bolus of a freely can also be used to reveal the intravascular characteris- filtered gadolinium-containing agent to measure fil- tics (blood perfusion) as they are usually not filtered tration capacity. Methods: The study was conducted through the glomerular membrane [1,2]. In contrary, sma- in mice subjected to complete unilateral uretera