re-parameterization the logistic model in assessing changes in the baroreceptor reflexre-parameterization物流模型在评估压力感受性反射的变化.pdf

Neuroscience Medicine, 2011, 2, 110-116 doi:10.4236/nm.2011.22016 Published Online June 2011 (http://www.SciRP.org/journal/nm) Re-parameterization of the Logistic Model in Assessing Changes in the Baroreceptor Reflex —Logistic Model for Changes in Baroreceptor Reflex 1 2 Shande Chen , Xiangrong Shi 1Department of Biostatistics, University of North Texas, Fort Worth, USA; 2Department of Integrative Physiology, University of North Texas, Health Science Center, Fort Worth, USA. Email: Shande.Chen@ Received March 16th, 2010; revised April 16th, 2010; accepted April 25th, 2010. ABSTRACT The logistic model is frequently used to describe the nonlinear relationship between systemic arterial pressure (SAP) and carotid sinus pressure (CSP). In this paper, we propose using maximum gain and saturation as parameters in the logistic model. By this method, the estimates and standard errors together with confidence intervals for maximum gain and saturation are direct outputs from the curve fitting, which also makes it easy to perform various hypotheses testing on these quantities. The method is illustrated by real life data from a study on the carotid baroreflex function during infusion of sodium nitroprusside, in which seven healthy, young men who were clinically proved to be free from any disease were studied. Their heart rate, arterial blood pressure and central venous pressure were measured. Neck pres- sure and neck suction protocol was carried out to selectively elicit changes in CSP and the responsiveness of SAP. Data were analyzed and compare before and after nitroprusside infusion. Our results showed that nitroprusside significantly decreased arterial blood pressure and central venous pressure, and significantly increased heart rate, and significantly augmented maximum gain of the carotid baroreflex function. Keywords : Blood Pressure, Carotid Sinus Pressure, Heart Rate, Mathematical