risk factors for prematurity among neonates from hiv positive mothers in cameroon早产的危险因素在新生儿从艾滋病毒阳性的母亲在喀麦隆.pdf

World Journal of AIDS, 2011, 1, 1-7 1 doi: 10.4236/wja.2011.11001 Published Online March 2011 (http://www.SciRP.org/journal/wja) Risk Factors for Prematurity among Neonates from HIV Positive Mothers in Cameroon 1,2 2 1 3 3 1 2 Taguebue J , Monebenimp F , Zingg W , Mve Koh V , Atchoumi A , Gervaix A , Tetanye E 1Department of Pediatrics and Adolescent Medicine, University Hospitals of Geneva, Geneva, Switzerland; 2Department of Pediat- rics, University of Yaoundé Hospital, Yaoundé, Cameroon; 3Department of Gynecology and Obstetrics, University of Yaoundé Hos- pital, Yaoundé Cameroon. Email: walter.zingg@hcuge.ch Received March 11th, 2011; revised March 15th, 2011; accepted March 18th . ABSTRACT Objective: Human immunodeficiency virus (HIV) infection is the most important chronic health condition among women in childbearing age in sub-Saharan Africa. There is sparse data about socio-economic factors in the context with adverse outcome in pregnancy. The objective of the study was to identify such factors for prematurity, low birth weight (LBW) and intrauterine growth retardation (IUGR) in infants born to HIV-positive women in Cameroon. Meth- ods: The study was done in Yaoundé between December 2001 and November 2007. Neonates born to HIV-positive mothers were monitored and clinical data as well as socio-economic factors were tested for association with prematur- ity, LBW and IUGR. Findings: In total, 264 neonates were analyzed. More prematurity occurred when mothers at- tended less than 4 prenatal care visits (OR [95% CI]: 2.7 [1.21 - 6.05]; p = 0.015). HIV-classification 1 resulted in more IUGR (OR [95% CI]): 3.15 [1.4 - 7.4]; p = 0.01) and L