schiff base sh11 with tuberculostatic and radical scavenging activities against inh-induced oxidative hepatic damage席夫碱sh11 tuberculostatic和自由基清除活性与inh-induced氧化肝损害.pdf

Advances in Bioscience and Biotechnology, 2012, 3, 1068-1075 ABB /10.4236/abb.2012.327130 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Schiff base SH11 with tuberculostatic and radical scavenging activities against INH-induced oxidative hepatic damage 1* 1 2 3 Nedyalka Georgieva , Zvezdelina Yaneva , Galina Nikolova , Svetlana Simova 1Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, Stara Zagora, Bulgaria 2Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria 3Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria * Email: nvgeorgieva@vmf.uni-sz.bg Received 8 August 2012; revised 11 September 2012; accepted 16 October 2012 ABSTRACT limitation of being hepatotoxic [3]. Despite the signifi- cant success in the chemotherapy of the tuberculosis, the By in vitro visible electron paramagnetic resonance exploration of new, more active and less toxic biologi- (EPR) spectrophotometry method we demonstrated cally active chemical compounds is still continuing. Iso- that N-isonicotinoyl-N’-(3-etoxy-2-hydroxybenzalde- nicotinoylhydrazones are compounds structurally rela- hyd) hydrazone (SH11) exhibits radical scavenging