schistosoma tegument proteins in vaccine and diagnosis development an update血吸虫皮蛋白疫苗和诊断的发展更新.pdf

Hindawi Publishing Corporation Journal of Parasitology Research Volume 2012, Article ID 541268, 8 pages doi:10.1155/2012/541268 Review Article Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update 1, 2 ˆ 1 Cristina Toscano Fonseca, Gardenia Braz Figueiredo Carvalho, Clarice Carvalho Alves,1 and Tatiane Teixeira de Melo1 1 Laboratorio de Esquistossomose, Centro de Pesquisas Rene Rachou, Fundac¸ao Oswaldo Cruz, Avenida Augusto de Lima 1715, ´ ´ ˜ Belo Horizonte,MG 30190-002, Brazil 2 Instituto Nacional de Ciencias e Tecnologia em Doenc¸as Tropicais (INCT-DT), Avenida Augusto de Lima 1715, ˆ Belo Horizonte, MG 30190-002, Brazil Correspondence should be addressed to Cristina Toscano Fonseca, ctoscano@cpqrr.fiocruz.br Received 27 July 2012; Accepted 24 September 2012 Academic Editor: Andrea Teixeira-Carvalho Copyright © 2012 Cristina Toscano Fonseca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagn