serum il-1, il-2, and il-6 in insulin-dependent diabetic children在胰岛素依赖型糖尿病患者血清il - 1、- 2和il - 6的孩子.pdf
- 1、本文档共7页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
serum il-1, il-2, and il-6 in insulin-dependent diabetic children在胰岛素依赖型糖尿病患者血清il - 1、- 2和il - 6的孩子
Hindawi Publishing Corporation
Mediators of Inflammation
Volume 2006, Article ID 59206, Pages 1–6
DOI 10.1155/MI/2006/59206
Research Communication
Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent
Diabetic Children
Yasar Dogan,1 Saadet Akarsu,1 Bilal Ustundag,2 Erdal Yilmaz,1 and Metin Kaya Gurgoze1
1 Department of Pediatrics, Medical Faculty, Firat University, 23119 Elazig, Turkey
2 Department of Biochemistry, Medical Faculty, Firat University, 23119 Elazig, Turkey
Received 10 July 2005; Accepted 28 October 2005
Insulin-dependent diabetes mellitus (IDDM) is a chronic disease characterized by T-cell-dependent autoimmune destruction of
the insulin-producing β cells in the pancreatic islets of Langerhans, resulting in an absolute lack of insulin. T cells are activated
in response to islet-dominant autoantigens, the result being the development of IDDM. Insulin is one of the islet autoantigens
responsible for the activation of T-lymphocyte functions, inflammatory cytokine production, and development of IDDM. The
aim of this study was to investigate serum concentrations of interleukin (IL)-1β, IL-2, IL-6, and tumor necrosis factor (TNF)-α in
children IDDM. The study population consisted of 27 children with IDDM and 25 healthy controls. Children with IDDM were
divided into three subgroups: (1) previously diagnosed patients (long standing IDDM) (n : 15), (2) newly diagnosed patients
with diabetic ketoacidosis (before treatment) (n : 12), and (3) newly diagnosed patients with diabetic ketoacidosis (after treatment
for two weeks) (n : 12). In all stages of diabetes higher levels of IL-1β and TNF-α and lower levels of IL-2 and IL-6 were detected.
Our data about elevated serum IL-1β, TNF-α and decreased IL-2, IL-6 levels in newly diagnosed IDDM patients in comparison
with longer standing cases
您可能关注的文档
- schatten class toeplitz operators on the bergman space伯格曼schatten类托普利兹运营商的空间.pdf
- scheduling aircraft landings at lss airport在lss机场调度飞机降落.pdf
- scfv antibody principles and clinical applicationscfv抗体原理和临床应用.pdf
- schauder basis, separability, and approximation property in intuitionistic fuzzy normed spaceschauder基础、可分性和近似属性在直觉模糊赋范空间.pdf
- scheduling chemotherapy catch 22 between cell kill and resistance evolution调度化疗赶上22细胞杀死和电阻之间的进化.pdf
- satellite derived geospatial irrigation performance indicators for benchmarking studies of irrigation systems卫星派生的地理空间灌溉灌溉系统性能指标为基准的研究.pdf
- scheduling in targeted transient surveys and a new telescope for chase调度目标瞬态的调查和追逐的新望远镜.pdf
- scheduling medical procedures how one single delay begets multiple subsequent delays调度医疗程序有一个延迟产生多个后续延误.pdf
- scheduling mobile data services in a bluetooth在蓝牙调度移动数据服务.pdf
- scheme for secure communication via information hiding based on key exchange and decomposition protocols通过信息隐藏方案安全通信基于密钥交换和分解协议.pdf
文档评论(0)