serum il-1, il-2, and il-6 in insulin-dependent diabetic children在胰岛素依赖型糖尿病患者血清il - 1、- 2和il - 6的孩子.pdf

serum il-1, il-2, and il-6 in insulin-dependent diabetic children在胰岛素依赖型糖尿病患者血清il - 1、- 2和il - 6的孩子.pdf

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serum il-1, il-2, and il-6 in insulin-dependent diabetic children在胰岛素依赖型糖尿病患者血清il - 1、- 2和il - 6的孩子

Hindawi Publishing Corporation Mediators of Inflammation Volume 2006, Article ID 59206, Pages 1–6 DOI 10.1155/MI/2006/59206 Research Communication Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent Diabetic Children Yasar Dogan,1 Saadet Akarsu,1 Bilal Ustundag,2 Erdal Yilmaz,1 and Metin Kaya Gurgoze1 1 Department of Pediatrics, Medical Faculty, Firat University, 23119 Elazig, Turkey 2 Department of Biochemistry, Medical Faculty, Firat University, 23119 Elazig, Turkey Received 10 July 2005; Accepted 28 October 2005 Insulin-dependent diabetes mellitus (IDDM) is a chronic disease characterized by T-cell-dependent autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans, resulting in an absolute lack of insulin. T cells are activated in response to islet-dominant autoantigens, the result being the development of IDDM. Insulin is one of the islet autoantigens responsible for the activation of T-lymphocyte functions, inflammatory cytokine production, and development of IDDM. The aim of this study was to investigate serum concentrations of interleukin (IL)-1β, IL-2, IL-6, and tumor necrosis factor (TNF)-α in children IDDM. The study population consisted of 27 children with IDDM and 25 healthy controls. Children with IDDM were divided into three subgroups: (1) previously diagnosed patients (long standing IDDM) (n : 15), (2) newly diagnosed patients with diabetic ketoacidosis (before treatment) (n : 12), and (3) newly diagnosed patients with diabetic ketoacidosis (after treatment for two weeks) (n : 12). In all stages of diabetes higher levels of IL-1β and TNF-α and lower levels of IL-2 and IL-6 were detected. Our data about elevated serum IL-1β, TNF-α and decreased IL-2, IL-6 levels in newly diagnosed IDDM patients in comparison with longer standing cases

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