serum leptin levels in patients with ocular and nonocular beh？ets disease患者血清中瘦素水平眼和nonocular本·等的疾病.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2007, Article ID 31986, 4 pages doi:10.1155/2007/31986 Clinical Study Serum Leptin Levels in Patients with Ocular and Nonocular Behc¸et’s Disease 1 2 1 2 ¨ ¨ ˘ Uc¸ler Kısa, ˘ ˘ F. Nilufer Yalc¸ındag, Figen Batıoglu, Ali Yalc¸ındag, 1 2 ¨ ¨ Ozden Ozdemir, ˘ and Osman C¸ aglayan 1 Department of Ophthalmology, Faculty of Medicine, Ankara University, 06100 Ankara, Turkey 2 Department of Clinical Biochemistry, Faculty of Medicine, Kırıkkale University, 71200 Kırıkkale, Turkey Received 9 February 2007; Accepted 13 March 2007 Aims . To investigate serum leptin levels in Behc¸et’s patients with or without ocular involvement compared with healthy subjects and the relationship between serum leptin and uveitis activity in patients with ocular involvement. Methods. Fifty-seven patients with Behc¸et’s disease and 20 healthy control subjects were included in this study. While 27 patients had ocular involvement (18 had acute uveitis, 9 had inactive ocular involvement), 30 did not have ocular disease. C-reactive protein, alpha 1-antitrypsin, and serum leptin levels were measured in all samples. Results. There was a significant difference between the patients with Behc¸et’s disease and control group for both logarithm of leptin (P = .000) and logarithm of CRP (P = .031). Logarithm of leptin in non- ocular Behc¸et’s patients was significantly higher compared to its level in ocular Behc¸et’s disease an