serum levels of tumor necrosis factor-α, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with helicobacter pylori-associated gastritis血清肿瘤坏死factor-α,白细胞介素- 6和interleukin-8不增加患胃病的患者幽门螺杆菌pylori-associated胃炎.pdf

Research Communication Mediators of Inflammation, 13(1), 25/ 28 (February 2004) Introduction : Helicobacter pylori (H. pylori ) is a Serum levels of tumor necrosis non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. H. factor-a, interleukin-6 and pylori- induced gastric mucosal cytokine overproduc- interleukin-8 are not increased in tion has been clearly documented previously. The stomach has a large surface area and continuous dyspeptic patients with spill-over of locally produced cytokines into the blood stream is a possibility. There are few and Helicobacter pylori-associated conflicting data on circulatory proinflammatory cy- gastritis tokine levels in patients with H. pylori infection. Materials and methods : Forty-two dyspeptic patients were enrolled into the study. The presence of H. pylori infection was diagnosed with antral histo- 1,CA 2 Taner Bayraktarog˘ lu , Ahmet Sukru Aras , ¸ ¨ ¨ pathologic examination. After overnight fasting; Selim Aydemir3 4 ¨ 3 , Can Davutog˘ lu , Yucel Ustundag˘ , ¨ ¨ serum samples were obtained from each patient to