serum positive for the autoantibody against the -adrenoceptor from chinese patients with congestive heart failure decreases in mouse cardiac myocytes血清对肾上腺素能受体的自身抗体阳性从中国充血性心力衰竭患者减少老鼠心脏细胞.pdf

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 143517, 7 pages doi:10.1155/2011/143517 Research Article Serum Positive for the Autoantibody against the β 1-Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases Iss in Mouse Cardiac Myocytes Yuan-yuan Wang,1, 2 Zhi-Yong Ma,1, 2 Xiao-Dong Li,3 Jian-chun Wang,3 Wei Zhang,1, 2 Li Li,1, 2 and Yun Zhang1, 2 1 Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China 2 Department of Cardiology, QiLu Hospital, Shandong University, Jinan 250012, China 3 Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China Correspondence should be addressed to Li Li, lili 8599@163.com Received 5 November 2010; Accepted 7 April 2011 Academic Editor: Stuart Mannering Copyright © 2011 Yuan-yuan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Autoantibodies targeting the β -adrenergic receptor (AAB-β ) display agonist-like effects, which may have a pathogenic role in 1 1 the progression of heart failure. Here, we used the electrophysiological recordings to explore the effects of AAB-β 1-positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current (Ito ) and the end 50 ms steady-state potassium current (I ) in mouse cardiac myocytes. We found that the AAB-β -positive serum had no effect on the