serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain灼口综合征患者血清白细胞介素- 6和关系与抑郁和感知疼痛.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2007, Article ID 45327, 4 pages doi:10.1155/2007/45327 Clinical Study Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain Qianming Chen,1 Juan Xia,2 Mei Lin,1 Hongmei Zhou,1 and Bingqi Li1 1 Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China 2 Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China Received 19 January 2007; Accepted 26 February 2007 Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively. Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P = .002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P = .011). However, no significant relations were found between interleukin-6 and HRSD scores (P = .317). Conclusions. Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as pre- cipitating factors in BMS etiopathogenesis. Copyright © 2007 Qianming Chen et al. This is an open access article distributed under the Creative Commons Attribution License