sex differences in cardiovascular control by nitric oxide in normotensive and hypertensive rats性别差异在心血管控制在正常血压和高血压的大鼠一氧化氮.pdf

Vol.2, No.8, 897-905 (2010) HEALTH doi:10.4236/health.2010.28133 Sex differences in cardiovascular control by nitric oxide in normotensive and hypertensive rats Oxana Semyachkina-Glushkovskaya*, Tatyana Anishchenko, Sergey Kapralov, Roman Novikov, Konstantin Skvorcov, Yana Kuznecova, Antonina Kuznecova Saratov State University, Saratov, Russia; *Corresponding Author: glushkovskaya@mail.ru Received 21 November 2009; revised 7 January 2010; accepted 9 January 2010. ABSTRACT vascular resistance to stress and development of hypertension. R Nitric oxide probably plays an important role in mechanisms determining sexual dimorphism Keywords: Nitric Oxide; Stress; Cardiovascular in the development of cardiovascular diseases, Stress-Reactivity; Sex-Differences including hypertension. Because stress together with gender are significant cardiovascular risk factors, we studied the role nitric oxide in car- 1. INTRODUCTION diovascular regulation in male and female nor- motensive and hypertensive rats under normal The clinical and experimental studies show that nitric and stress conditions. Experiments were per- oxide (NO) plays an important role in regulation of the formed in mongrel normotensive and hyperten- cardiovascular homeostasis. So, NO inhibits platelet sive (two kidney, one clip) rats of both sexes, aggregation and adhesion [1], prevents neointimal plaque weighing 200-250g. The study of mean arterial progression [2], NO is also involved in the baroreflex pressure and heart rate was carri